Navigating the holidays while on weight-loss medications like Wegovy and Ozempic

LOS ANGELES - The holiday season often revolves around food, drink, and gatherings with family and friends—factors that can complicate the routines of those on weight-loss medications like Wegovy, Ozempic, and Mounjaro. These drugs, designed to suppress appetite by targeting GLP-1 and GIP hormones, require consistent dosing schedules to be effective. However, the temptation to adjust injections to accommodate big meals can backfire, experts warn.

Why sticking to your medication schedule matters

Skipping or delaying weekly doses might seem like a quick fix for enjoying holiday indulgences, but it can lead to negative consequences. Dr. Andres Acosta, a gastroenterology and obesity specialist at Mayo Clinic, advises patients against disrupting their schedules. "Stopping the medication even temporarily means you may need to return to lower doses and slowly work your way back up, delaying progress," he explained.

Delaying doses—such as shifting an injection from Wednesday to Friday—can also result in the reappearance of initial side effects like nausea, vomiting, and diarrhea. For some, this adjustment can make restarting the medication challenging, says Dr. Andre Teixeira, a bariatric specialist at Orlando Health. "Some people never tolerate the higher doses again after stopping," he notes, likening the hormonal effects to side effects some women experience when switching birth control methods.

Tips for managing the holidays without altering doses

Experts agree that the key to enjoying holiday meals and traditions while staying on track with weight-loss medications lies in preparation and moderation. Here’s how to navigate the season:

• Plan meals wisely: Save your appetite for celebratory meals by opting for lighter meals earlier in the day. "Skipping a big breakfast or lunch can help balance out a festive dinner," says Acosta.
• Stay active: Incorporate movement into your day, whether it’s a walk in the park, a hike, or even a shopping trip to the mall. Physical activity can help counterbalance holiday indulgences.
• Set boundaries: Don’t feel pressured to overeat or drink at gatherings. If you’re comfortable, share your goals with family and friends to help manage expectations.
• Mind your portions: Enjoy holiday dishes in smaller servings to prevent overeating and avoid potential side effects from the medication.

Alcohol and weight-loss medications

Many people on GLP-1 and GIP drugs find that alcohol doesn’t pair well with their medication. Side effects like nausea and gastrointestinal discomfort can be exacerbated by drinking. A recent WeightWatchers survey found that nearly half of users on these medications reduced their alcohol consumption—whether to avoid side effects or as part of a broader commitment to healthier habits.

Balancing health and holiday traditions

Navigating the holidays while on weight-loss medications requires careful planning but doesn’t mean you have to miss out. "The holidays can be enjoyed while staying on track with your health goals," says Acosta. With thoughtful preparation, people taking medications like Wegovy or Ozempic can celebrate without compromising their progress.